+--------------------------------------------------------------------+
| |
| TRANS (SUBROUTINE) |
| |
+--------------------------------------------------------------------+
MEANING: TRANS subroutine
CONTEXT: User-supplied subroutine; for use with PREDPP
USAGE:
SUBROUTINE TRANS (ITRANS,IRGG,GG,NETAS)
USE SIZES, ONLY: ISIZE,DPSIZE,LVR
INTEGER(KIND=ISIZE) :: IRGG,NPETAS,ITRANS
REAL(KIND=DPSIZE) :: GG(IRGG,LVR+1,LVR+1)
DISCUSSION:
The TRANS subroutine translates (or transforms) the values for a set
of basic PK parameters modeled in PK to a set of values for the inter-
nal parameters required by the ADVAN. The PREDPP Library has a number
of TRANS subroutines, representing different possible parameteriza-
tions in PK, from which the user may choose. If a suitable translator
is not found in the Library, the user may write his own.
Input/Output argument:
ITRANS
ITRANS=1: TRANS has been called for initialization at the begin-
ning of a NONMEM problem; one such call per problem. ITRANS must
be reset by TRANS to a number in the range 1-8999. This number
appears on NONMEM output, allowing the user to identify the TRANS
routine being used.
ITRANS=2: On input the GG array has stored in it the values com-
puted by PK (except that were any PK parameter modeled in its
logarithm form in PK, PREDPP would have already exponentiated its
typical/subject-specific value and multiplied its eta derivatives
by its exponentiated typical/subject-specific value). On output
the GG array should have stored in it the values that would be
computed by PK were the internal parameters of the ADVAN modeled
directly in PK (and none in their logarithmic form).
ITRANS=4: TRANS has been called during the Simulation Step. Only
the first column of the GG array need be computed as with
ITRANS=2. Other columns need not be computed.
GG The array of PK parameters and their eta derivatives.
The array is described elsewhere; (See pk).
Input argument:
NETAS
The number of population etas in the problem.
Certain variables are available in modules. Their use is optional.
Variables in read/write modules:
IERPRD NETEXT ETEXT
(See PRED Exit Code).
(See PRED Error Message).
Variables in read-only commons:
NOETAS, SECOND
(See Partial Derivative Indicators).
When SECOND is true, PREDPP requires second-partial derivatives of
etas.
REFERENCES: Guide VI Section III.M
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