+--------------------------------------------------------------------+
 |                                                                    |
 |                        RECORDS=ID EXAMPLE 2                        |
 |                                                                    |
 +--------------------------------------------------------------------+

 This fully-worked out example shows how the RECORDS=ID option of $DATA
 and the INCLUDE statement may be used to analyze the Theophyline  data
 set  THEOPP  as  separate  individuals.  The NONMEM control file is as
 follows.

   $PROB  THEOPHYLLINE POPULATION DATA; Analysis of Individuals
   ; Modification of CONTROL5 control steam
   $INPUT      ID DOSE=AMT TIME CP=DV WT
   $DATA       THEOPP RECS=ID
   ;RECS=ID:  Data set will be read until ID changes or end-of-file

   $SUBROUTINES  ADVAN2

   $PK
   ;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
   ;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
   ;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
   ;SCALING PARAMETER=VOLUME/WT SINCE DOSE IS WEIGHT-ADJUSTED
      CALLFL=1
      KA=THETA(1)
      K=THETA(2)
      CL=THETA(3)*WT
      SC=CL/K/WT

   $THETA  (.1,3,5) (.008,.08,.5) (.004,.04,.9)
   $OMEGA .4
   ;For single subject data OMEGA is residual variance.

   $ERROR
      Y=F+ERR(1)
   ;ERR must be used instead of EPS.

   $EST MAXEVAL=450  PRINT=5

   $COV SPECIAL
   ;SPECIAL is required to obtain the variance-covariance matrix for
   ;single-subject data.

   $TABLE ID DOSE WT TIME NOPRINT ONEHEADER FILE=indest.tab

   $TABLE ID KA K CL SC NOPRINT FIRSTONLY ONEHEADER NOAPPEND
          FILE=indest.par
   INCLUDE indest.txt 11
   ; INCLUDE: Inserts copies of the file named indest.txt for each
   ; additional individual.

 The contents of file indest.txt are:

   $PROB  THEOPHYLLINE POPULATION DATA; Analysis of Individuals
   $INPUT      ID DOSE=AMT TIME CP=DV WT
   $DATA       THEOPP RECS=ID NOREWIND
   ;NOREWIND: data set will be read starting after the previous individual

   $THETA  (.1,3,5) (.008,.08,.5) (.004,.04,.9)

   $OMEGA .4
   ;For single subject data OMEGA is residual variance

   $EST MAXEVAL=450  PRINT=5

   $COV SPECIAL
   ;SPECIAL is required to obtain the variance-covariance matrix for
   ;single-subject data

   $TABLE ID DOSE WT TIME NOPRINT ONEHEADER FORWARD FILE=indest.tab

   $TABLE ID KA K CL SC NOPRINT FIRSTONLY ONEHEADER FORWARD NOAPPEND
     FILE=indest.par

 An alternate approach for single-subject data is available with NONMEM |
 7.  OMEGA diagonal values are fixed to a special value 1.0E+06.        |
 See  Guide  Introduction_7  "Single-Subject  Analysis using Population |
 with Unconstrained ETAs ".

REFERENCES: Guide Introduction_7

  
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