+--------------------------------------------------------------------+
| |
| COMPARTMENT INITIALIZATION: A_0 |
| |
+--------------------------------------------------------------------+
MEANING: PREDPP-PK global variables
CONTEXT: PK routine
USAGE:
USE PRMOD_REAL, ONLY: A_0,DA_0,D2A_0
GLOBAL DECLARATION:
USE SIZES, ONLY: PC,LVR,DPSIZE
REAL(KIND=DPSIZE) :: A_0(PC),DA_0(PC,LVR),D2A_0(PC,LVR,LVR)
DISCUSSION:
PREDPP sets A_0FLG to 1 (See compartment initialization: a_0flg) at a
call to PK with the first event record of an individual record (if the
data are population data), with the first event record of the data set
(if the data are single-subject data), and with a reset record. At
such times, the amounts in the various compartments can be set by the
PK routine. It can do this by storing the initial values for the
state vector and its partials in A_0,DA_0,D2A_0. The amount in the
output compartment can not be set.
A_0
A_0(n) = the amount for compartment n
DA_0
DA_0(n,i) = the derivative of A_0(n) wrt eta(i)
D2A_0
D2A_0(n,i,j) = the second derivative of A_0(n) wrt eta(i), eta(j)
(lower-triangular; j=1, ..., i)
There is a one-to-one correspondence between A_0,DA_0,D2A_0 and
A,DAETA,D2AETA (See State Vector: A).
NM-TRAN includes A_0,DA_0,D2A_0 in the PK routine when the $PK block
includes references to variables A_0FLG, A_0, or A_INITIAL, or when
verbatim code is present.
(See Compartment Initialization: A_0FLG, State Vector: A).
Location prior to NONMEM 7: prdpk3
REFERENCES: None.
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