+--------------------------------------------------------------------+
 |                                                                    |
 |                    PK_PD_SIMULTANEOUS_1 EXAMPLE                    |
 |                                                                    |
 +--------------------------------------------------------------------+

 This  is  an  example  for  simultaneous analysis of PK and direct PD.
 Kinetics are one compartment.  (See PK_PD_simultaneous_2, PK_PD_simul-
 taneous_3).

 $PROBLEM   SIMULT PK/PD - ADVAN3
 ; THE DATA FILE CONTAINS BOTH CP AND EFFECT OBSERVATIONS.
 ; WHEN DV IS A CP OBSERVATION, CMT = 1 (OR 0)
 ; WHEN DV IS AN EFFECT OBSERVATION, CMT =2
 $DATA   data
 $INPUT  ID TIME DV AMT=DOSE CMT
 $SUBROUTINES ADVAN3
 $PK
    K  = THETA(1)*EXP(ETA(1))
    K12= .001*K                     ; TRIVIAL LOSS TO EFFECT CMPT
    K21= THETA(2)*EXP(ETA(2))       ; KEO
    S1=  THETA(3)*EXP(ETA(3))       ; V1 FOR DRUG
    EMAX=THETA(4)*EXP(ETA(4))
    C50= THETA(5)*EXP(ETA(5))
    S2=  S1*K12/K21                 ; SO THAT CESS = CPSS
 $ERROR
    IF (CMT.EQ.2) THEN
    Y = EMAX*F/(C50+F)*EXP(ERR(2))   ; DV = EFFECT IF CMT=2
    ELSE
    Y = F*EXP(ERR(1))                ; DV = CP IF CMT=1 (OR 0)
    ENDIF
 ; ADD APPROPRIATE $THETA, $OMEGA, $SIGMA, $ESTIMATION, ETC.

REFERENCES: Guide IV Section V.C.6
REFERENCES: Guide VI Section IV.B.2, VII.C.3


  
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