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| OUTPUT FRACTION PARAMETER |
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MEANING: Output fraction (F0) parameter for PREDPP
CONTEXT: Additional PK Parameters
USAGE:
$PK
F0= ....
DISCUSSION:
The output fraction parameter is used with PREDPP. It is an optional
additional PK parameter. With NM-TRAN, it are symbolized in the $PK
block by any one of the reserved variables FO, F0, or Fn, where n is
the compartment number of the output compartment.
With any of the kinetic models a (peripheral) output compartment is
always present. Associated with this compartment is a PK parameter,
the output fraction , denoted here by Fo. Of the entire amount, Ao, of
drug introduced into the system by various dosage patterns and then
eliminated from the system during a given time interval, a fraction Fo
of
Ao goes into this output compartment.
If the output compartment is never turned on, the output fraction can
be ignored. If the value of the output fraction is not computed in PK,
it is always understood to be 1
The use of Fo depends on the assumption that the rate of change of
drug amount in the output compartment is linear in the other compart-
ment amounts. Other than this linearity restriction, the system can be
nonlinear.
Tyically, the output compartment is used for urine observations, and |
the central for plasma observations, with any ADVAN.
(See cmt, pk, $pk, default_compartment).
REFERENCES: Guide IV Section V.C.5
REFERENCES: Guide V Section 6.9
REFERENCES: Guide V Section 7.4.1
REFERENCES: Guide V Section 7.4.5
REFERENCES: Guide V Section 7.4.3.3
REFERENCES: Guide VI Section III.F.7
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