+--------------------------------------------------------------------+
| |
| CTUP |
| |
+--------------------------------------------------------------------+
MEANING: NONMEM-PRED global variables
CONTEXT: PRED routine
USAGE:
USE NMPR_REAL, ONLY CTUP,DCTUP,DDCTUP
GLOBAL DECLARATION:
USE SIZES, ONLY: DPSIZE,LVR
REAL(KIND=DPSIZE) :: CTUP,DCTUP(LVR),DDCTUP(LVR,LVR)
DISCUSSION:
An observation may be the event that the value of a normally distrib-
uted variable falls in a given interval. The likelihood for this
event may be automatically computed. With the data record containing
the observation, one specifies the mean and variance of the variable
for NONMEM, as usual, and one sets CTUP to the upper endpoint of the
interval. If with population data, this endpoint depends on an eta
variable, then the first- and second-derivatives of the endpoint with
respect to etas should also be set. Derivatives equal to 0 need not
be explicitly set, and the only elements of DDCTUP that need be set
are those in the lower triangle. CTUP may be set in a $PRED or $ERROR
abbreviated code, and then NM-TRAN automatically sets the derivatives.
NONMEM can detect when CTUP is not set. When CTUP is set, the Lapla-
cian estimation method must be used.
CTLO may be used in conjunction with CTUP.
(See ctlo).
PR_CT is the estimated probability that an observation will be of the
category in question.
(See pr_ct, CTLO_TUP_Probability:_PR_CT).
Limitation:
May not be used with the LIKELIHOOD or -2LOGLIKELIHOOD options.
Location prior to NONMEM 7: nmpr14
REFERENCES: None.
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