+--------------------------------------------------------------------+
 |                                                                    |
 |                          CONTROL7 EXAMPLE                          |
 |                                                                    |
 +--------------------------------------------------------------------+

 This is file CONTROL7 from NONMEM distribution media
 It is discussed in Guide IV, Appendix VIII.

 $PROB  THEOPHYLLINE   POPULATION DATA
 $INPUT      ID DOSE=AMT TIME CP=DV WT
 $DATA       THEOPP
 $SUBROUTINES  ADVAN6  TOL=5
 $MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) COMP=(CENTRAL,DEFOBS,NOOFF)
 $PK
 ;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
 ;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
 ;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
 ;SCALING PARAMETER=VOLUME/WT SINCE DOSE IS WEIGHT-ADJUSTED
    CALLFL=1
    KA=THETA(1)+ETA(1)
    KE=THETA(2)+ETA(2)
    CL=THETA(3)*WT+ETA(3)
    S2=CL/KE/WT
 $THETA  (.1,3,5) (.008,.08,.5) (.004,.04,.9)
 $OMEGA BLOCK(3)  6 .005 .0002 .3 .006 .4
 $DES
    DADT(1)=-KA*A(1)
    DADT(2)= KA*A(1)-KE*A(2)
 $ERROR
    Y=F+EPS(1)
 $SIGMA  .4
 $EST     MAXEVAL=450  PRINT=5
 $COV
 $TABLE          ID DOSE WT TIME
 $SCAT           (RES WRES) VS TIME BY ID

 The data is file THEOPP from the NONMEM distribution media.  The first
 individual's data follows.

          1      4.02      0.         .       79.6
          1       .        0.         .74       .
          1       .        0.25      2.84       .
          1       .        0.57      6.57       .
          1       .        1.12     10.5        .
          1       .        2.02      9.66       .
          1       .        3.82      8.58       .
          1       .        5.1       8.36       .
          1       .        7.03      7.47       .
          1       .        9.05      6.89       .
          1       .       12.12      5.94       .
          1       .       24.37      3.28       .

REFERENCES: Guide III Section VI.3
REFERENCES: Guide IV Appendix VI, VIII


  
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