+--------------------------------------------------------------------+
 |                                                                    |
 |                          CONTROL4 EXAMPLE                          |
 |                                                                    |
 +--------------------------------------------------------------------+

 This is file CONTROL4 from NONMEM distribution media

 $PROB  THEOPHYLLINE   POPULATION DATA
 $INPUT      ID DOSE TIME CP=DV WT
 $DATA       THEO

 $PRED
 ;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
 ;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
 ;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
 ;DOSE=WT-ADJUSTED DOSE (MG/KG)
 ;DS=NON-WT-ADJUSTED DOSE (MG)
    IF (DOSE.NE.0) THEN
       DS=DOSE*WT
       W=WT
    ENDIF
    KA=THETA(1)+ETA(1)
    KE=THETA(2)+ETA(2)
    CL=THETA(3)*W+ETA(3)
    D=EXP(-KE*TIME)-EXP(-KA*TIME)
    E=CL*(KA-KE)
    F=DS*KE*KA/E*D
    Y=F+EPS(1)

 $THETA  (.1,3,5) (.008,.08,.5) (.004,.04,.9)
 $OMEGA BLOCK(3)  6 .005 .0002 .3 .006 .4
 $SIGMA  .4

 $EST     MAXEVAL=450  PRINT=5
 $COV
 $TABLE          ID DOSE WT TIME
 $SCAT           (RES WRES) VS TIME BY ID

 The  data  is file THEO from the NONMEM distribution media.  The first
 individual's data follows.

          1      4.02      0.         .74     79.6
          1       .        0.25      2.84       .
          1       .        0.57      6.57       .
          1       .        1.12     10.5        .
          1       .        2.02      9.66       .
          1       .        3.82      8.58       .
          1       .        5.1       8.36       .
          1       .        7.03      7.47       .
          1       .        9.05      6.89       .
          1       .       12.12      5.94       .
          1       .       24.37      3.28       .

REFERENCES: Guide III Section VI.3
REFERENCES: Guide IV Appendix II


  
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