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| BIOAVAILABILITY FRACTION PARAMETER |
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MEANING: Bioavailability fraction (F) parameter for PREDPP
CONTEXT: Additional PK Parameters
USAGE:
$PK
F1= ....
DISCUSSION:
Bioavailability fraction parameters are used with PREDPP. They are
optional additional PK parameters. With each possible dose compart-
ment of the kinetic model (the output compartment is not a possible
dose compartment), there is associated one bioavailability fraction
(parameter), symbolized in the $PK record by the reserved variable Fn,
where n is the number of the compartment.
If the amount on a dose record is A, and the bioavailability fraction
is F, only the fraction F of A actually appears in the dose compart-
ment (either instantaneously at the time the dose enters the compart-
ment - with a bolus dose, or over a period of time - with a regular
infusion; the bioavailability fraction does not apply to a steady-
state infusion).
Bioavailability fractions are optional in the sense that bioavailabil-
ity fractions associated with compartments never used as dose compart-
ments may be ignored. The values of bioavailability fractions that are
not computed in PK are always understood to be 1.
When additional doses are specified on a dose event record, the
bioavailability fraction applies to the dose and to all the additional
doses. When a steady-state dose is specified on a dose event record,
the bioavailability fraction applies to the dose and to all implied
doses leading to the steady-state.
(See cmt, pk, $pk, default_compartment).
REFERENCES: Guide IV Section V.C.5
REFERENCES: Guide V Section 6.8, 7.4.4
REFERENCES: Guide VI Section III.F.6, V.F.1, V.H
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