+--------------------------------------------------------------------+
 |                                                                    |
 |                         BAYES EXAMPLE 10L                          |
 |                                                                    |
 +--------------------------------------------------------------------+

 This  is  example10l.ctl  from  the NONMEM 7 distribution medium.  It,
 along with the data file, can be found in the examples directory.

 $PROB  F_FLAG04est2a.ctl
 $INPUT C ID DOSE=AMT TIME DV WT TYPE
 $DATA example10l.csv IGNORE=@

 $SUBROUTINES  ADVAN2 TRANS2

 $PK
    CALLFL=1
    MU_1=THETA(1)
    KA=DEXP(MU_1+ETA(1))
    MU_2=THETA(2)
    V=DEXP(MU_2+ETA(2))
    MU_3=THETA(3)
    CL=DEXP(MU_3+ETA(3))
    SC=V/1000

 $THETA  1.6 2.3 0.7 0.1 0.1

 $OMEGA BLOCK (3)
 0.5
 0.01 0.5
 0.01 0.01 0.5

 ; Because THETA(4) and THETA(5) have no inter-subject variability
 ; associated with them, the algorithm must use a more computationally
 ; expensive gradient evaluation for these two parameters

 $SIGMA 0.1

 $PRIOR NWPRI
 ; Priors to Omegas
 $OMEGAP BLOCK (3)
 0.09 FIX
 0.0 0.09
 0.0 0.0 0.09
 $OMEGAPD (3 FIX)

 $ERROR
     EXPP=THETA(4)+F*THETA(5)
 IF (TYPE.EQ.0) THEN
 ; PK Data
     F_FLAG=0
     Y=F+F*ERR(1) ; a prediction
  ELSE
 ; Categorical data
     F_FLAG=1
 ; Use protected exponent PEXP, to avoid numerical overflow
     A=PEXP(EXPP)
     B=1+A
     Y=DV*A/B+(1-DV)/B      ; a likelihood
  ENDIF

 $EST METHOD=ITS INTER LAP NITER=1000 PRINT=5 SIGL=6 NSIG=2 NOABORT
      NOPRIOR=1 CTYPE=3 CITER=10 CALPHA=0.05 FILE=example10l.ext
 ; Because of categorical data, which can make conditional density highly
 ; non-normal, select a t-distribution with 4 degrees of freedom for
 ; importance sampling proposal density
 $EST METHOD=IMP INTER LAP NITER=1000 PRINT=1 ISAMPLE=300 DF=4 IACCEPT=1.0
 $EST METHOD=IMP EONLY=1 NITER=5 ISAMPLE=1000 PRINT=1 DF=4 IACCEPT=1.0
      MAPITER=0

 $EST METHOD=SAEM EONLY=0 INTER LAP NBURN=2000 NITER=1000 PRINT=50
      DF=0 IACCEPT=0.4
 $EST METHOD=IMP EONLY=1 NITER=5 ISAMPLE=1000 PRINT=1 DF=4
      IACCEPT=1.0 MAPITER=0

 $EST METHOD=BAYES NBURN=3000 NSAMPLE=3000 PRINT=100
      FILE=example10l.txt DF=0 IACCEPT=0.4 NOPRIOR=0

 $EST METHOD=COND LAP INTER MAXEVAL=9999 PRINT=1 FILE=example10l.ext
      NOPRIOR=1

 $COV UNCONDITIONAL PRINT=E MATRIX=R SIGL=10
 $TABLE ID DOSE WT TIME TYPE DV A NOPRINT FILE=example10l.tab

REFERENCES: Guide Introduction_7

  
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