+--------------------------------------------------------------------+
 |                                                                    |
 |                               ADVAN3                               |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Choice of Pharmacokinetic Model for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [ADVAN=]ADVAN3

 SAMPLE:
 $SUBROUTINE ADVAN3

 DISCUSSION:
 ADVAN3  is  a routine in PREDPP's library which implements the kinetic
 equations for the Two Compartment Linear Model.

 Compt.   Function     Initial   On/Off    Dose      Default    Default
 No.                   Status    Allowed   Allowed   for Dose   for Obs.
 1        Central      On        No        Yes       Yes        Yes
 2        Peripheral   On        No        Yes       No         No
 3        Output       Off       Yes       No        No         No

 TRANS routines that may  be  used:  TRANS1,  TRANS3,  TRANS4,  TRANS5,
 TRANS6
 Basic PK parameters with TRANS1:

      K (rate constant of elimination)
      K12 (rate constant from central to peripheral)
      K21 (rate constant from peripheral to central)

 Basic PK parameters with TRANS3: (See TRANS3).

 Basic PK parameters with TRANS4: (See TRANS4).

 Basic PK parameters with TRANS5: (See TRANS5).

 Basic PK parameters with TRANS6: (See TRANS6).

 Additional PK parameters:

      S1 - Scale for central compartment (also called SC)
      S2 - Scale for peripheral compartment
      S3 - Scale for output compartment (also called S0)
      F1 - Bioavailability for central compartment
      F2 - Bioavailability for peripheral compartment
      R1 - Rate for central compartment
      R2 - Rate for peripheral compartment
      D1 - Duration for central compartment
      D2 - Duration for peripheral compartment
      ALAG1 - Absorption lag for central compartment
      ALAG2 - Absorption lag for peripheral compartment
      F0 - Output fraction (also called F3, FO)
      XSCALE - Time scale
      MTIME(i) - Model event times

REFERENCES: Guide VI Section VII.C.3


  
Go to main index.
  

    Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007,10/2012)