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| ADVAN2 |
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MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVAN2
SAMPLE:
$SUBROUTINE ADVAN2
DISCUSSION:
ADVAN2 is a routine in PREDPP's library which implements the kinetic
equations for the One Compartment Linear Model with First Order
Absorption.
Compt. Function Initial On/Off Dose Default Default
No. Status Allowed Allowed for Dose for Obs.
1 Depot Off Yes Yes Yes No
2 Central On No Yes No Yes
3 Output Off Yes No No No
TRANS routines that may be used: TRANS1, TRANS2
Basic PK parameters with TRANS1:
K (rate constant of elimination)
KA (rate constant of absorption)
Basic PK parameters with TRANS2: (See TRANS2).
Additional PK parameters:
S1 - Scale for depot compartment
S2 - Scale for central compartment (also called SC)
S3 - Scale for output compartment (also called S0)
F1 - Bioavailability for depot compartment
F2 - Bioavailability for central compartment
R1 - Rate for depot compartment
R2 - Rate for central compartment
D1 - Duration for depot compartment
D2 - Duration for central compartment
ALAG1 - Absorption lag for depot compartment
ALAG2 - Absorption lag for central compartment
F0 - Output fraction (also called F3, FO)
XSCALE - Time scale
MTIME(i) - Model event times
REFERENCES: Guide VI Section VII.C.2
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