+--------------------------------------------------------------------+
 |                                                                    |
 |                           ADDL DATA ITEM                           |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Additional Dose (ADDL) data item for PREDPP
 CONTEXT: $INPUT record and NONMEM data set

 USAGE:
 $INPUT ... ADDL ...

 DISCUSSION:
 ADDL labels PREDPP's additional dose (ADDL) data item.  The additional
 dose data item is optional.  In a dose or reset-dose event  record  it
 describes how many additional doses, exactly like the present ("initi-
 ating") dose, should be given.  The interdose interval (II) data  item
 gives the time between the additional doses (See ii).

 When ADDL is 0, no additional doses are given.

 For  non-steady-state  doses,  ADDL should be a positive number if and
 only if the II data item is a positive  number.   II  gives  the  time
 between additional doses.

 For steady-state infusions, ADDL must be 0.

 For  other  steady-state  doses, ADDL is optional. If it is a positive
 number, it continues the pattern of implied doses beyond  the  steady-
 state  dose.  The additional doses of the pattern are non-steady state
 doses.

 With NM75 there is a new way of computing SS, the Empirical method, in
 which  there is no SS data item, and a negative value of ADDL requests
 the computation.  This is described separately.
 (See empirical_SS).
 (See Guide Introduction_7 "An Empirical  Method  of  Achieving  Steady
 State")

 For  observation,  other-type  and reset event records, ADDL should be
 zero.

 The following two data record fragments specify the same set of doses:

      TIME   AMT   ADDL   II    DV
      10.    15.   0      0     .
      15.    .     .      .     25.7
      20.    10.   0      0     .
      22.    15.   0      0     .
      34.    15.   0      0     .
      36.    .     .      .     30.2

      TIME   AMT   ADDL   II    DV
      10.    15.   2      12.   .
      15.    .     .      .     25.7
      20.    10.   0      0     .
      36.    .     .      .     30.2

 The observation at time 15 and the extra dose at time 20 do not affect
 the regular dosing regimen (doses at times 10, 22, and 34).

 There is a discussion of user (concomitant) data items used to compute
 PK parameters that are relevant to ADDL doses; (See $BIND).

REFERENCES: Guide VI Section V.K


  
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