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| RATE DATA ITEM |
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MEANING: Dose Rate (RATE) data item for PREDPP
CONTEXT: $INPUT record and NONMEM data set
USAGE:
$INPUT ... RATE ...
DISCUSSION:
RATE labels PREDPP's dose rate (RATE) data item. The dose rate data
item is optional. In a dose or reset-dose event record it can take
four kinds of values.
0 The dose is an instantaneous bolus dose.
>0 The dose is an infusion, and the value of RATE gives its rate.
If this is not a steady-state infusion, the AMT data item must be
positive also. If this is a steady-state dose event record, both
AMT and RATE may be 0; (See ss dose).
-1 The dose is a zero-order bolus dose, i.e., an infusion, whose
rate is modeled in the PK routine. As an example, suppose the
compartment being dosed is numbered 1 (e.g., the CMT data item
contains 1, or it contains 0 and compartment 1 is the default
compartment for doses). The $PK abbreviated code must define a
value for R1, the rate parameter for compartment 1, e.g.,
R1=THETA(4)+ETA(4)
-2 The dose is a zero-order bolus dose, i.e., an infusion, whose
duration is modeled in the PK routine. As an example, suppose
the compartment being dosed is numbered 1 as above. The $PK
abbreviated code must define a value for D1, the duration parame-
ter for compartment 1, e.g., D1=THETA(4)+ETA(4)
RATE must be 0 for observation, other-type, and reset event records.
(See dose, steady_state_dose).
REFERENCES: Guide VI Section V.E
REFERENCES: Guide V Section 6.8
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