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| CMT PCMT DATA ITEM |
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MEANING: Compartment (CMT) and Prediction Compartment (PCMT) data
items for PREDPP
CONTEXT: $INPUT record and NONMEM data set
USAGE:
$INPUT ... CMT PCMT ...
DISCUSSION:
CMT and PCMT label PREDPP's compartment (CMT) and prediction compart-
ment (PCMT) data items. The compartment and prediction compartment
data items are optional. They may be used separately or together.
Their meanings depend on the particular kind of event record.
Observation Event:
CMT specifies the number of the observation compartment (the com-
partment whose scaled drug amount appears as F in the error rou-
tine). When this number is that of the output compartment, it is
allowed to have a negative sign, in which case the output com-
partment is turned off after F is obtained.
This is also the case for an output-type compartment, which is a |
compartment with attributes INITIALOFF and NODOSE. (With a com- |
partment n which is not the output compartment or an output-type |
compartment, two records must be used, with the same TIME value: |
the first with CMT=n and EVID=1 to obtain the observation, and |
the second with CMT=-n and EVID=2 to turn the compartment off.)
By convention, the number of the output compartment may also be |
given by the CMT data item as the number 1000 (this is true |
regardless of the type of the event record). With small models |
(number of compartments <= 99), this number may also be given as |
100. With versions of NONMEM prior to 7.3, only small models are |
possible, and only 100 may be used. |
When CMT is 0, the default compartment for observations is used.
PCMT is ignored.
Dose Event:
CMT specifies the number of the compartment into which the dose
is introduced. The dose compartment is turned on if it was pre-
viously off. When CMT is 0, the default compartment for doses
receives the dose.
PCMT specifies the number of the compartment for which an F value
is computed.
PCMT may be specified as 1000 or 100 to indicate the default com- |
partment for output, similarly to CMT above. |
When PCMT is 0, the default compartment for observations is used.
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
When CMT is 0, no change is made in the status of any compart-
ment.
PCMT is the same as for dose events.
Reset Event:
CMT is ignored.
PCMT is the same as for dose events.
Reset-Dose Event:
CMT and PCMT are the same as for dose events.
Guide V (Introductory Guide) has an example of how urine collections
and observations of urine concentration can be described in the data
file, along with observations of plasma concentrations. See Chapter
6, Section 9, The Output Compartment: Urine Collections and Observa-
tions
REFERENCES: Guide VI Section V.H
REFERENCES: Guide V Section 6.9
Go to main index.
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