+--------------------------------------------------------------------+
 |                                                                    |
 |                               TRANS6                               |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Choice of Translator Routine for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [TRANS=]TRANS6

 SAMPLE:
 $SUBROUTINE ADVAN3 TRANS6

 DISCUSSION:
 TRANS6 is a routine in PREDPP's library which can be used with ADVAN3,
 ADVAN4, ADVAN11, and ADVAN12.  It performs a reparameterization of the
 basic PK parameters.

 Basic PK parameters for ADVAN3, TRANS6:

      ALPHA   alpha
      BETA    beta
      K21     rate constant (peripheral to central)

      Relationship:
      K=ALPHA*BETA/K21
      K12=ALPHA+BETA-K21-K

      Constraint:

      Assuming that ALPHA < BETA, then ALPHA < K21 < BETA.
      The roles of ALPHA and BETA are exchangeable.

 Basic PK parameters for ADVAN4, TRANS6:

      ALPHA   alpha
      BETA    beta
      K32     rate constant (peripheral to central)
      KA      absorption rate constant

      Relationship:
      K=ALPHA*BETA/K32
      K23=ALPHA+BETA-K32-K
      KA is unchanged

      Constraint:

      Assuming that ALPHA < BETA, then ALPHA < K32 < BETA.
      The roles of ALPHA and BETA are exchangeable.

 Basic PK parameters for ADVAN11, TRANS6:

      ALPHA   alpha
      BETA    beta
      GAMMA   gamma
      K21     rate constant (peripheral 1 to central)
      K31     rate constant (peripheral 2 to central)

      Relationship:
      K=ALPHA*BETA*GAMMA/(K21*K31)
      K13=(P+K31*K31-K31*S-K*K21)/(K21-K31)
      K12=S-K-K13-K21-K31
      where
         S=ALPHA+BETA+GAMMA
         P=ALPHA*BETA+ALPHA*GAMMA+BETA*GAMMA

      Constraint:

      Assuming that ALPHA<BETA<GAMMA, then
        ALPHA<K21<BETA<K31<GAMMA
      or
        ALPHA<K31<BETA<K21<GAMMA.
      The  roles of ALPHA, BETA, GAMMA, K21, K31, K12, and K13 are sym-
      metric and are exchangeable.

 Basic PK parameters for ADVAN12, TRANS6:

      ALPHA   alpha
      BETA    beta
      GAMMA   gamma
      K32     rate constant (peripheral 1 to central)
      K42     rate constant (peripheral 2 to central)
      KA      absorption rate constant

      Relationship:
      K=ALPHA*BETA*GAMMA/(K32*K42)
      K24=(P+K42*K42-K42*S-K*K32)/(K32-K42)
      K23=S-K-K24-K32-K42
      where
         S=ALPHA+BETA+GAMMA
         P=ALPHA*BETA+ALPHA*GAMMA+BETA*GAMMA
      KA is unchanged

      Constraint:

      Assuming that ALPHA<BETA<GAMMA, then
        ALPHA<K32<BETA<K42<GAMMA
      or
        ALPHA<K42<BETA<K32<GAMMA.
      The roles of ALPHA, BETA, GAMMA, K32, K42, K23, and K24 are  sym-
      metric and are exchangeable.

 REFERENCES: None.


  
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