+--------------------------------------------------------------------+
 |                                                                    |
 |                               TRANS4                               |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Choice of Translator Routine for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [TRANS=]TRANS4

 SAMPLE:
 $SUBROUTINE ADVAN3 TRANS4

 DISCUSSION:
 TRANS4 is a routine in PREDPP's library which can be used with ADVAN3,
 ADVAN4, ADVAN11, or ADVAN12.  It performs a reparameterization of  the
 basic PK parameters to the internal parameters K, K12, K21, and KA.

 Basic PK parameters for ADVAN3, TRANS4:

      CL   clearance
      V1   central volume
      Q    intercompartmental clearance
      V2   peripheral volume

      Relationship:
      K=CL/V1
      K12=Q/V1
      K21=Q/V2

 Basic PK parameters for ADVAN4, TRANS4:

      CL   clearance
      V2   central volume
      Q    intercompartmental clearance
      V3   peripheral volume
      KA   absorption rate constant

      Relationship:
      K=CL/V2
      K23=Q/V2
      K32=Q/V3
      KA is unchanged

 Basic PK parameters for ADVAN11, TRANS4:

      CL   clearance
      V1   central volume
      Q2   intercompartmental clearance (central and periph. 1)
      V2   peripheral 1 volume
      Q3   intercompartmental clearance (central and periph. 2)
      V3   peripheral 2 volume

      Relationship:
      K=CL/V1
      K12=Q2/V1
      K21=Q2/V2
      K13=Q3/V1
      K31=Q3/V3

 Basic PK parameters for ADVAN12, TRANS4:

      CL   clearance
      V2   central volume
      Q3   intercompartmental clearance (central and periph 1)
      V3   peripheral 1 volume
      Q4   intercompartmental clearance (central and periph 2)
      V4   peripheral 2 volume
      KA   absorption rate constant

      Relationship:
      K=CL/V2
      K23=Q3/V2
      K32=Q3/V3
      K24=Q4/V2
      K42=Q4/V4
      KA=KA

REFERENCES: Guide VI Section VII.C.3, VII.C.4


  
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