+--------------------------------------------------------------------+
| |
| FINAL PARAMETER ESTIMATE |
| |
+--------------------------------------------------------------------+
MEANING: Final estimates of parameters THETA, OMEGA, SIGMA
CONTEXT: NONMEM output
DISCUSSION:
A page with the title FINAL PARAMETER ESTIMATE is printed as part of
every NONMEM output.
If the Estimation Step was NOT run, then the values printed are the
initial parameter estimates specified for the problem.
If the Estimation Step WAS run, then the values printed are the final
parameter estimates.
These estimates of parameters are used by NONMEM to compute the objec-
tive function value printed on the page with title "MINIMUM VALUE OF
OBJECTIVE FUNCTION" and to compute predicted values for Tables and
Scatterplots.
******************** FINAL PARAMETER ESTIMATE ***************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3
1.94E+00 1.02E-01 3.20E+01
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1
ETA1 8.99E-01
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1
ETA1 9.48E-01
This example is from a run involving single-subject data, so there is
no SIGMA matrix.
With NONMEM 7.2 and higher, the correlation matrix is included. It is
computed from the covariance matrix, whether or not the Estimation
step is not run.
(See initial parameter estimate).
With NONMEM 7.3 and higher, the $THETAR record may be used to trans- |
form final estimates of THETA before they are reported in the NONMEM |
output. |
(See $thetar).
REFERENCES: Guide V Section 10.5
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