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| CONTROL6 EXAMPLE |
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This is file CONTROL6 from NONMEM distribution media.
It is discussed in Guide IV, Appendix VIII.
$PROB THEOPHYLLINE POPULATION DATA
$INPUT ID DOSE=AMT TIME CP=DV WT
$DATA THEOPP
$SUBROUTINES ADVAN7
$MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) COMP=(CENTRAL,DEFOBS,NOOFF)
$PK
;THETA(1)=MEAN ABSORPTION RATE CONSTANT (1/HR)
;THETA(2)=MEAN ELIMINATION RATE CONSTANT (1/HR)
;THETA(3)=SLOPE OF CLEARANCE VS WEIGHT RELATIONSHIP (LITERS/HR/KG)
;SCALING PARAMETER=VOLUME/WT SINCE DOSE IS WEIGHT-ADJUSTED
CALLFL=1
K12=THETA(1)+ETA(1)
K20=THETA(2)+ETA(2)
CL=THETA(3)*WT+ETA(3)
S2=CL/K20/WT
$THETA (.1,3,5) (.008,.08,.5) (.004,.04,.9)
$OMEGA BLOCK(3) 6 .005 .0002 .3 .006 .4
$ERROR
Y=F+EPS(1)
$SIGMA .4
$EST MAXEVAL=450 PRINT=5
$COV
$TABLE ID DOSE WT TIME
$SCAT (RES WRES) VS TIME BY ID
The data is file THEOPP from the NONMEM distribution media. The first
individual's data follows.
1 4.02 0. . 79.6
1 . 0. .74 .
1 . 0.25 2.84 .
1 . 0.57 6.57 .
1 . 1.12 10.5 .
1 . 2.02 9.66 .
1 . 3.82 8.58 .
1 . 5.1 8.36 .
1 . 7.03 7.47 .
1 . 9.05 6.89 .
1 . 12.12 5.94 .
1 . 24.37 3.28 .
REFERENCES: Guide III
REFERENCES: Guide IV Appendix VI, VIII
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