+--------------------------------------------------------------------+
| |
| CELS |
| |
+--------------------------------------------------------------------+
MEANING: CELS subroutine
CONTEXT: NONMEM utility routine
This feature is not fully documented. The interested user may be able
to obtain more information by studying the appropriate sections of
NONMEM code and previous examples that may be available from advanced
users.
DISCUSSION:
CELS is a NONMEM utility routine. It may be called by a user-supplied
CCONTR routine. It computes the default contribution to the condi-
tional objective function from a L2 record.
Certain NONMEM error messages refer to CELS, for example:
PROGRAM TERMINATED BY OBJ, ERROR IN CELS
WITH INDIVIDUAL 1 (IN INDIVIDUAL RECORD ORDERING)
INTRAINDIVIDUAL VARIANCE OF DATA FROM OBS RECORD 1 ESTIMATED TO BE 0
A common situation giving rise to this message is the use of a propor-
tional intra-individual error model while some predicted values
for actual observations are zero or close to zero. (For example, if
the first dose is an infusion and there is a "base- line" observa-
tion at the start of the infusion, the predicted level will be
zero.)
CELS must not be called when a user-supplied CRIT routine is used.
REFERENCES: None.
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