+--------------------------------------------------------------------+
| |
| BAYES EXAMPLE 9 |
| |
+--------------------------------------------------------------------+
This is example9.ctl from the NONMEM 7 distribution medium. It, along
with the data file, can be found in the examples directory.
;Model Desc: Two compartment Model, Using ADVAN3, TRANS4
;Project Name: nm7examples
;Project ID: NO PROJECT DESCRIPTION
$PROB RUN# Example 9 (from samp5l)
$INPUT C SET ID JID TIME DV=CONC AMT=DOSE RATE EVID MDV CMT
CLX V1X QX V2X SDIX SDSX
$DATA example9.csv IGNORE=C
$SUBROUTINES ADVAN3 TRANS4 OTHER=aneal.f90
$PK
MU_1=THETA(1)
MU_2=THETA(2)
MU_3=THETA(3)
MU_4=THETA(4)
CL=DEXP(MU_1+ETA(1))
V1=DEXP(MU_2+ETA(2))
Q=DEXP(MU_3+ETA(3))
V2=DEXP(MU_4+ETA(4))
S1=V1
$ERROR
Y = F + F*EPS(1)
; Initial values of THETA
$THETA
(0.001, 2.0) ;[LN(CL)]
(0.001, 2.0) ;[LN(V1)]
(0.001, 2.0) ;[LN(Q)]
(0.001, 2.0) ;[LN(V2)]
;INITIAL values of OMEGA
$OMEGA BLOCK(4)
0.05 ;[P]
0.01 ;[F]
0.05 ;[P]
0.01 ;[F]
0.01 ;[F]
0.05 ;[P]
0.01 ;[F]
0.01 ;[F]
0.01 ;[F]
0.05 ;[P]
;Initial value of SIGMA
$SIGMA
(0.6 ) ;[P]
$EST METHOD=SAEM INTERACTION FILE=example9.ext NBURN=5000
NITER=500 PRINT=10 NOABORT SIGL=6 CTYPE=3 CINTERVAL=100
CITER=10 CALPHA=0.05
REFERENCES: Guide Introduction_7
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