+--------------------------------------------------------------------+
 |                                                                    |
 |                               ADVAN4                               |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Choice of Pharmacokinetic Model for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [ADVAN=]ADVAN4

 SAMPLE:
 $SUBROUTINE ADVAN4

 DISCUSSION:
 ADVAN4  is  a routine in PREDPP's library which implements the kinetic
 equations for the  Two  Compartment  Linear  Model  with  First  Order
 Absorption.

 Compt.   Function     Initial   On/Off    Dose      Default    Default
 No.                   Status    Allowed   Allowed   for Dose   for Obs.
 1        Depot        Off       Yes       Yes       Yes        No
 2        Central      On        No        Yes       No         Yes
 3        Peripheral   On        No        Yes       No         No
 4        Output       Off       Yes       No        No         No

 TRANS  routines  that  may  be  used:  TRANS1, TRANS3, TRANS4, TRANS5,
 TRANS6

 Basic PK parameters with TRANS1:

      K   (rate constant of elimination)
      K23 (rate constant from central to peripheral)
      K32 (rate constant from peripheral to central)
      KA  (rate constant of absorption)

 Basic PK parameters with TRANS3: (See TRANS3).

 Basic PK parameters with TRANS4: (See TRANS4).

 Basic PK parameters with TRANS5: (See TRANS5).

 Basic PK parameters with TRANS6: (See TRANS6).

 Additional PK parameters:

      S1 - Scale for depot compartment
      S2 - Scale for central compartment (also called SC)
      S3 - Scale for peripheral compartment
      S4 - Scale for output compartment (also called S0)
      F1 - Bioavailability for depot compartment
      F2 - Bioavailability for central compartment
      F3 - Bioavailability for peripheral compartment
      R1 - Rate for depot compartment
      R2 - Rate for central compartment
      R3 - Rate for peripheral compartment
      D1 - Duration for depot compartment
      D2 - Duration for central compartment
      D3 - Duration for peripheral compartment
      ALAG1 - Absorption lag for depot compartment
      ALAG2 - Absorption lag for central compartment
      ALAG3 - Absorption lag for peripheral compartment
      F0 - Output fraction (also called F4, FO)
      XSCALE - Time scale
      MTIME(i) - Model event times

REFERENCES: Guide VI Section VII.C.4


  
Go to main index.
  

    Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007,10/2012)