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| ADVAN10 |
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MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVAN10
SAMPLE:
$SUBROUTINE ADVAN10
DISCUSSION:
ADVAN10 is a routine in PREDPP's library which implements the kinetic
equations for the One Compartment Model with Michaelis-Menten Elimina-
tion.
Compt. Function Initial On/Off Dose Default Default
No. Status Allowed Allowed for Dose for Obs.
1 Central On No Yes Yes Yes
2 Output Off Yes No No No
TOL is required; (See $SUBROUTINES).
If steady-state doses are present, steady-state routine SS6 is used,
and consequently a $DES block (or user-supplied DES routine) is
required. Unless there are steady-state infusions, it may be a "dummy
routine".
(See Guide VI, section VII.C.6)
TRANS routines that may be used: TRANS1
Basic PK parameter with TRANS1:
VM (maximum rate)
KM (Michaelis constant)
Additional PK parameters:
S1 - Scale for central compartment (also called SC)
S2 - Scale for output compartment (also called S0)
F1 - Bioavailability for central compartment
R1 - Rate for central compartment
D1 - Duration for central compartment
ALAG1 - Absorption lag for central compartment
F0 - Output fraction (also called F2, FO)
XSCALE - Time scale
MTIME(i) - Model event times
Required PREDPP Library subroutines:
ADVAN10 - MMPHI
REFERENCES: Guide VI Section VII.C.6, VII.C.10
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