+--------------------------------------------------------------------+
 |                                                                    |
 |                               ADVAN1                               |
 |                                                                    |
 +--------------------------------------------------------------------+

 MEANING: Choice of Pharmacokinetic Model for PREDPP
 CONTEXT: Option of NM-TRAN $SUBROUTINES record

 USAGE:
 $SUBROUTINES [ADVAN=]ADVAN1

 SAMPLE:
 $SUBROUTINE ADVAN1

 DISCUSSION:
 ADVAN1  is  a routine in PREDPP's library which implements the kinetic
 equations for the One Compartment Linear Model.

 Compt.   Function   Initial   On/Off    Dose      Default    Default
 No.                 Status    Allowed   Allowed   for Dose   for Obs.
 1        Central    On        No        Yes       Yes        Yes
 2        Output     Off       Yes       No        No         No

 TRANS routines that may be used: TRANS1, TRANS2

 Basic PK parameter with TRANS1:

      K (rate constant of elimination)

 Basic PK parameters with TRANS2: (See TRANS2).

 Additional PK parameters:

      S1 - Scale for central compartment (also called SC)
      S2 - Scale for output compartment (also called S0)
      F1 - Bioavailability for central compartment
      R1 - Rate for central compartment
      D1 - Duration for central compartment
      ALAG1 - Absorption lag for central compartment
      F0 - Output fraction (also called F2, FO)
      XSCALE - Time scale
      MTIME(i) - Model event times

REFERENCES: Guide VI Section VII.C.1


  
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