The appearance of this 5th edition of the PREDPP Guide corresponds to the release of PREDPP 7.5.0 and NONMEM 7.5.0.
This preface lists signifcant changes vs. the 4th edition of this guide, PREDPP 7.4.0 and NONMEM 7.4.0.
Significant changes since the previous edition are marked with bars.
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ADVAN16 |
General Nonlinear Model with
Delay Equations Using RADAR5.
See Chapter VII, Section C.16.
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ADVAN17 |
General Nonlinear Model with
Delay Equations and Equilibrium Compartments Using RADAR5.
See Chapter VII, Section C.17.
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ADVAN18 |
General Nonlinear Model with
Delay Equations Using DDE_Solver.
See Chapter VII, Section C.18.
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PRED can cause data records to be ignored |
$INFN, $PK, or $PRED, can use reserved variables PRED_IGNORE_DATA_TEST and PRED_IGNORE_DATA to provide an extension to the $DATA IGNORE=(list), ACCEPT=(list) feature.
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A_UFLG,A_U |
The compartment update feature allows $PK to update amounts in compartments at any value of MTIME.
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Empirical Method of Achieving Steady State |
When ADDL<0, this requests that steady state be computed by giving as many doses as needed until steady state is reached.
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ITASK_ and STOP_TIME |
Avoiding overshoot in ADVAN9, ADVAN13, ADVAN14, and ADVAN15
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Tolerance for ADVAN 9,13,14,15,16,17,18 |
ODE ADVANs can have an absolute
tolerance for each compartment, e.g. ANRD(1)=10.
ODE ADVANs except 14 and 15 can have a relative tolerance
for each compartment, e.g. NRD(1)=6.
Values of absolute (ANRD) and relative (NRD) tolerance can
be set for each NONMEM step, e.g.,
IF(NM_STEP==EST_STEP) ANRD(1)=10.
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