The NM-TRAN outputs obtained from using the NM-TRAN control stream listed in chapter V, along with the NM-TRAN data set listed in Appendix VI, are given on the following pages of this appendix.
Data Set - FDATA
1 4.02 0. 79.6 1 1
1 0. .74 0 0
1 0.25 2.84 0 0
1 0.57 6.57 0 0
1 1.12 10.5 0 0
1 2.02 9.66 0 0
1 3.82 8.58 0 0
1 5.1 8.36 0 0
1 7.03 7.47 0 0
1 9.05 6.89 0 0
1 12.12 5.94 0 0
1 24.37 3.28 0 0
2 4.4 0. 72.4 1 1
2 0. 0. 0 0
2 .27 1.72 0 0
2 .52 7.91 0 0
2 1. 8.31 0 0
2 1.92 8.33 0 0
2 3.5 6.85 0 0
2 5.02 6.08 0 0
2 7.03 5.4 0 0
2 9. 4.55 0 0
2 12. 3.01 0 0
2 24.3 .90 0 0
3 4.53 0. 70.5 1 1
3 0. 0. 0 0
3 .27 4.4 0 0
3 .58 6.9 0 0
3 1.02 8.2 0 0
3 2.02 7.8 0 0
3 3.62 7.5 0 0
3 5.08 6.2 0 0
3 7.07 5.3 0 0
3 9. 4.9 0 0
3 12.15 3.7 0 0
3 24.17 1.05 0 0
4 4.4 0. 72.7 1 1
4 0. 0. 0 0
4 .35 1.89 0 0
4 .6 4.6 0 0
4 1.07 8.6 0 0
4 2.13 8.38 0 0
4 3.5 7.54 0 0
4 5.02 6.88 0 0
4 7.02 5.78 0 0
4 9.02 5.33 0 0
4 11.98 4.19 0 0
4 24.65 1.15 0 0
5 5.86 0. 54.6 1 1
5 0. 0. 0 0
5 .3 2.02 0 0
5 .52 5.63 0 0
5 1. 11.4 0 0
5 2.02 9.33 0 0
5 3.5 8.74 0 0
5 5.02 7.56 0 0
5 7.02 7.09 0 0
5 9.1 5.9 0 0
5 12. 4.37 0 0
5 24.35 1.57 0 0
6 4. 0. 80. 1 1
6 0. 0. 0 0
6 .27 1.29 0 0
6 .58 3.08 0 0
6 1.15 6.44 0 0
6 2.03 6.32 0 0
6 3.57 5.53 0 0
6 5. 4.94 0 0
6 7. 4.02 0 0
6 9.22 3.46 0 0
6 12.1 2.78 0 0
6 23.85 .92 0 0
7 4.95 0. 64.6 1 1
7 0. .15 0 0
7 .25 .85 0 0
7 .5 2.35 0 0
7 1.02 5.02 0 0
7 2.02 6.58 0 0
7 3.48 7.09 0 0
7 5. 6.66 0 0
7 6.98 5.25 0 0
7 9. 4.39 0 0
7 12.05 3.53 0 0
7 24.22 1.15 0 0
8 4.53 0. 70.5 1 1
8 0. 0. 0 0
8 .25 3.05 0 0
8 0.52 3.05 0 0
8 .98 7.31 0 0
8 2.02 7.56 0 0
8 3.53 6.59 0 0
8 5.05 5.88 0 0
8 7.15 4.73 0 0
8 9.07 4.57 0 0
8 12.1 3. 0 0
8 24.12 1.25 0 0
9 3.1 .0 86.4 1 1
9 .0 0. 0 0
9 .3 7.37 0 0
9 .63 9.03 0 0
9 1.05 7.14 0 0
9 2.02 6.33 0 0
9 3.53 5.66 0 0
9 5.02 5.67 0 0
9 7.17 4.24 0 0
9 8.8 4.11 0 0
9 11.6 3.16 0 0
9 24.43 1.12 0 0
10 5.5 0. 58.2 1 1
10 0. .24 0 0
10 .37 2.89 0 0
10 .77 5.22 0 0
10 1.02 6.41 0 0
10 2.05 7.83 0 0
10 3.55 10.21 0 0
10 5.05 9.18 0 0
10 7.08 8.02 0 0
10 9.38 7.14 0 0
10 12.1 5.68 0 0
10 23.7 2.42 0 0
11 4.92 0. 65. 1 1
11 0. 0. 0 0
11 .25 4.86 0 0
11 .5 7.24 0 0
11 .98 8. 0 0
11 1.98 6.81 0 0
11 3.6 5.87 0 0
11 5.02 5.22 0 0
11 7.03 4.45 0 0
11 9.03 3.62 0 0
11 12.12 2.69 0 0
11 24.08 .86 0 0
12 5.3 0. 60.5 1 1
12 0. 0. 0 0
12 .25 1.25 0 0
12 .5 3.96 0 0
12 1. 7.82 0 0
12 2. 9.72 0 0
12 3.52 9.75 0 0
12 5.07 8.57 0 0
12 7.07 6.59 0 0
12 9.03 6.11 0 0
12 12.05 4.57 0 0
12 24.15 1.17 0 0
Control Stream - FCON
FILE FSTREAM PROB THEOPHYLLINE POPULATION DATA DATA 1 0 144 7 0 ITEM 1 4 7 11 1 0 0 0 0 0 0 INDX 6 3 2 0 0 0 0 0 0 0 0 LABL ID DOSE TIME CP WT EVID MDV FORM (5E6.0,2F2.0) STRC 3 3 1 0 0 0 1 1 0 STRC 1 3 THCN 1 0 0 THTA 3 .08 .04 LOWR .1 .008 .004 UPPR 5 .5 .9 BLST 6 .005 .3 .0002 .006 .4 DIAG .4 ESTM 0 450 3 5 0 0 0 0 0 0 0 COVR 0 0 0 0 0 TABL 1 1 0 0 TABL 4 1 0 2 0 5 0 3 0 SCAT 1 2 SCAT 3 9 1 1 0 0 0 0 0 SCAT 3 10 1 1 0 0 0 0 0
File Stream - FSTREAM
DATA FDATA ****
Report - FREPORT
NM-TRAN VERSION II LEVEL 1.0
SUBROUTINES FROM THE PREDPP LIBRARY:
PRED PREDI CHECK SADVAN ADVAN2 SSS0 TRANS1 INFN
GENERATED DP SUBROUTINES:
PK ERROR
NONMEM SUBROUTINES: ALL
Generated and User-Supplied Subroutines - FSUBS
The NONMEM VI versions are shown. With NONMEM 7 and higher, MODULES are used rather than COMMONS.
SUBROUTINE PK(ICALL,IDEF,THETA,IREV,EVTREC,N,INDXS,IRGG,GG,NETAS)
IMPLICIT DOUBLE PRECISION (A-Z)
REAL EVTREC
SAVE
INTEGER ICALL,IDEF,IREV,N,INDXS,IRGG,NETAS
DIMENSION IDEF(7,*),THETA(*),EVTREC(IREV,*),INDXS(*),GG(IRGG,11,*)
COMMON/PRRAND/ETA(10),EPS(10)
COMMON/PROCM1/NEWIND
INTEGER NEWIND
COMMON/ROCM12/MSEC
INTEGER MSEC
COMMON/NMPRD4/KA,K,CL,SC,Y,A00011,A00012,A00015,A00020,A00021
COMMON/NMPRD4/A00014,BBBBBB(0989)
IF (ICALL.LE.1) THEN
IDEF(1,01)=-9
IDEF(1,02)= 1
IDEF(3,02)= 4
CALL GETETA(ETA)
RETURN
ENDIF
IF (NEWIND.NE.2) THEN
IF (ICALL.EQ.4) THEN
CALL SIMETA(ETA)
ELSE
CALL GETETA(ETA)
ENDIF
ENDIF
WT=EVTREC(N,05)
KA=THETA(01)+ETA(01)
C A00011 = DERIVATIVE OF KA W.R.T. ETA(01)
A00011=1.D0
K=THETA(02)+ETA(02)
C A00012 = DERIVATIVE OF K W.R.T. ETA(02)
A00012=1.D0
CL=THETA(03)*WT+ETA(03)
SC=CL/K/WT
B00001=1.D0/K/WT
C A00014 = DERIVATIVE OF SC W.R.T. ETA(03)
A00014=B00001
B00002=-CL/K/K/WT
C A00015 = DERIVATIVE OF SC W.R.T. ETA(02)
A00015=B00002*A00012
GG(01,1,1)=K
GG(01,03,1)=A00012
GG(03,1,1)=KA
GG(03,02,1)=A00011
GG(04,1,1)=SC
GG(04,03,1)=A00015
GG(04,04,1)=A00014
IF (MSEC.EQ.1) THEN
B00003=-1.D0/K/K/WT
C A00016 = DERIVATIVE OF B00001 W.R.T. ETA(02)
A00016=B00003*A00012
B00004=-1.D0/K/K/WT
B00005=CL/K/K/K/WT
C A00018 = DERIVATIVE OF B00002 W.R.T. ETA(02)
A00018=B00005*A00012
B00006=CL/K/K/K/WT
C A00019 = DERIVATIVE OF B00002 W.R.T. ETA(02)
A00019=B00006*A00012+A00018
C A00020 = DERIVATIVE OF A00015 W.R.T. ETA(02)
A00020=A00012*A00019
C A00021 = DERIVATIVE OF A00015 W.R.T. ETA(03)
A00021=A00012*B00004
GG(04,03,03)=A00020
GG(04,04,03)=A00021
ENDIF
RETURN
END
SUBROUTINE ERROR
(ICALL,IDEF,THETA,IREV,EVTREC,N,INDXS,F,G,HH)
IMPLICIT DOUBLE PRECISION (A-Z)
REAL EVTREC
SAVE
INTEGER ICALL,IDEF,IREV,N,INDXS
DIMENSION IDEF(*),THETA(*),EVTREC(IREV,*),INDXS(*),G(10,*)
DIMENSION HH(10,*)
COMMON/PRRAND/ETA(10),EPS(10)
COMMON/ROCM12/MSEC
INTEGER MSEC
COMMON/NMPRD4/KA,K,CL,SC,Y,A00011,A00012,A00015,A00020,A00021
COMMON/NMPRD4/A00014,BBBBBB(0989)
IF (ICALL.LE.1) THEN
IDEF(2)=2
HH(1,1)=1.0D0
RETURN
ENDIF
IF (ICALL.EQ.4) THEN
CALL SIMEPS(EPS)
ENDIF
Y=F+EPS(01)
F=Y
RETURN
END
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