NONMEM Users Guide Part I - Users Basic Guide
References

NONMEM Users Guide Part I - Users Basic Guide

References

Beal, S.L. (1984a). "Population pharmacokinetic data and parameter estimation based on their first two statistical moments." Drug Metabolism Reviews 15, 173-193.

Beal, S.L. (1984b). "Asymptotic properties of optimization estimators for the independent not identically distributed case with application to extended least squares estimators." Technical Report of the Division of Clinical Pharmacology, University of California, San Francisco, pp. 46.

Beal, S.L. and Sheiner, L.B. (1988). "Heteroscedastic nonlinear regression." Technometrics 30, 327-338.

Fletcher, R. (1972). "FORTRAN subroutines for minimization by quasi-Newton methods." Technical Report AERE-R7125. Theoretical Physics Division, UKAEA Research Group, Atomic Energy Research Establishment, Harwell, England. pp. 28.

Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcel Dekker, Inc., New York.

Hoadley, B. (1971). "Asymptotic properties of maximum likelihood estimators for the independent not identically distributed case." Annals of Mathematical Statistics 42, 1977-1991.

Jennrich, R. (1969). "Asymptotic properties of nonlinear least-square estimators." Annals of Mathematical Statistics 40, 633-643.

Nelder, J. and Mead, R. (1964). "A simplex method for function minimization." Computer Journal 7, 308.

Sheiner, L., Rosenberg, B., and Marathe, V. (1977). "Estimation of population characteristics of pharmacokinetic parameters from routine clinical data." Journal of Pharmacokinetics and Biopharmaceutics 5, 445-479.

Sheiner, L.B., and Beal, S.L. (1980). "Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model; routine clinical pharmacokinetic data." Journal of Pharmacokinetics and Biopharmaceutics 8, 553-571.

Sheiner, L.B., and Beal, S.L. (1981). "Evaluation of methods for estimating population pharmacokinetic parameters. II. Biexponential model; experimental pharmacokinetic data." Journal of Pharmacokinetics and Biopharmaceutics 9, 635-651.

Sheiner L.B., and Beal, S.L. (1983). "Evaluation of methods for estimating population pharmacokinetic parameters. III. Monoexponential model; routine clinical pharmacokinetic data." Journal of Pharmacokinetics and Biopharmaceutics 11, 303-319.

Sheiner, L.B., and Beal, S.L. (1985). "Pharmacokinetic parameter estimates from several least-squares procedures: Superiority of extended least squares." Journal of Pharmacokinetics and Biopharmaceutics 13, 185-201.

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